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And on the half‐life of tolbutamide ﹒ Int J Clin Phar macol Biophar m，1976，13.3 ﹒ Zilly W，Breimer DD，Richter E ﹒ Induction of drug metabolismin man after rifampicin treat ment measured by increased hexobarbital and tolbutamide clear ance ﹒ Eur J Clin Phar macol，1975，9（2‐.