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1 ﹒ Spiller RC ﹒ Problems and challenges in the design of irritable bowel syndrome clinical trials：experience frompublished trials ﹒ AmJ Med，1999，107：91S‐97S ．.9 ﹒ Guthrie E，Barlow J，Fernandes L，et al ﹒ Changesin toleranceto rectal distension correlate wi ......