45﹒Clinical Evaluation of Hyaluronic Acid Combined with Tolmetin in the Treatment of Osteoarthritis

The treatment of osteoarthritis（OA）of the knee is directed towards the relief of symp toms ． Nonsteroidal anti‐inflammatory drugs（NSAIDs）play an important role due to their dual analgesic and anti‐inflammatory action ． Side effects are the primary problems in many pa tients。And no adverse effects were observed ． The results sug gest that the formulation may represent a valuable approach to the patients with OA of the knee with more efficacy and safety ．.