郭宗儒.毒性风险与药物分子设计.药学进展, 2012,36:1-13。High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor ( UIC-94017 ) active against multidrug-resistant clinical strains .Design of highly potent noncovalent thrombin inhibitors that utilize a novel lipophilic binding pocket in the thrombin active site .Steuber H, Heine A,Klebe G . Structural and thermodynamic study on aldose reductase:nitro-substituted inhibitors with strong enthalpic binding contribution .
……