[治疗]□丙卡巴肼（Procarbazine）□

D 尚无胎儿危险性的系统性临床研究。但临床个案病例报道显示，妊娠早期使用具有明显的致畸作用。一例行治疗性流产，胎儿患有肾易位，且肾发育不全。一例妊娠24周流产，胎儿双脚均为四指，且患有并趾症。在出生后随访的3～19年间，未见生长、智力发育以及细胞遗传学方面的异常。 尚无该方面的研究资料。鉴于该药具有明显的致畸作用，哺乳期妇女在用药期间应停止哺乳。 ［1］Schapira DV，Cludley AE.Successful pregnancy fol owing continuous treatment with combination chemotherapy before conception and through out pregnancy.Cancer.1984；54∶800-803 ［2］Daly H，McCann SR，Hanrat y TD，et al.Successful pregnancy during combination chemotherapy for Hodgkin′s disease.Acta Haematol（Ba sel）.1980；64∶154-156 ［3］Wel s JH，Marshal JR，Carbone PP.Procarbazine therapy for Hodgkin′s disease in early pregnancy.JAMA.1968；205∶935-937 ［4］Garret MJ.Teratogenic ef ects of combination chemotherapy.Ann Intern Med.1974；80∶667 ［5］Mennuti MT，Shepard TH，Mel man WJ.Fetal renal malformation fol ow ing treatment of Hodgkin′s disease during pregnancy.Obstet Gynecol. 1975；46∶194-196 ［6］Thomas PR，Biochem D，Peckham MJ.The investigation and manage ment of Hodgkin′s disease in the pregnant patient.Cancer 1976；38∶1443-1451 ［7］Aviles A，Diaz-Maqueo JC，Talavera A，et al.Growth and development of children of mothers treated with chemotherapy during pregnancy.Cur rent status of 43 children.Am J Hematol.1991；36∶243-248 （崔 毅）