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2 ﹒ Schaefer MG，Plowman BK，Morreale AP，et al ﹒ Interaction of rofecoxib and cele coxib with warfarin ﹒ AmJ Health Syst Phar m，2003，60.4 ﹒ Karim A，Tolbert D，Piergies A，et al ﹒ Celecoxib does not significantly alter the phar macokinetics or hypoprothrombinemic effect of warfarinin healthy subjects ﹒ J Clin Phar macol，2000，40.A randomized，double‐blind，controlled trial ﹒ Ann Phar ma cother，2006，40（7‐.