凡能引起肾小管‐间质性肾炎(tubulo‐interstitial nephritis,TI N),特别是可引起慢性间质性肾炎(chronic interstitial nephritis,CI N)的肾毒物质,均可引起肾间质纤维化。肾毒物质引起的间质性肾炎虽然是以急性间质性肾炎(acute interstitial nephritis,AI N)为多见,但肾毒物质引起的CI N在文献中也累有报道,此类肾毒物质主要有:肾毒药物。传统的止痛药物如扑热息痛、水杨酸类药物、吡唑酮(pyrazolone,等,也是 ......